Research Abstract
Influence of anti-oestrogens on the specific binding in vitro of (3H)oestradiol by cytosol of rat mammary tumours and human breast carcinomata.
Powell-Jones W, Jenner DA, Blamey RW, Davies P, Griffiths K
The Biochemical journal
Jul 1, 1975
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Abstract
The anti-oestrogenic potential of two nitrogen-mustard-containing compounds, I.C.I. 79792 and I.C.I. 85966, was studied. I.C.I. 85966 usually did not decrease specific binding of [3H]oestradiol by breast-tumour cytoplasmic proteins. I.C.I. 79792 decreased specific [3H]oestradiol binding, but not to the same extent as similar concentrations of I.C.I. 46474, diethylstilboestrol or dibutyldihydrostilboestrol.
External References
- PubMed ID:
- 173302
- DOI:
- 10.1042/bj1500071
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