Inhibition of bleomycin-induced pulmonary fibrosis in SD rats by sea cucumber peptides.
AI Summary
Key Findings
Abstract
BACKGROUND: Pulmonary fibrosis (PF) is the terminal manifestation of a type of pulmonary disease, which seriously affects the respiratory function of the body, and with no effective cure for treatment. This study evaluated the effect of sea cucumber peptides (SCP) on bleomycin-induced SD rat PF. RESULTS: SCP can inhibit the PF induced by bleomycin. PF and SCP did not affect the food intake of rats, but PF reduced the body weight of rats, and SCP could improve the weight loss. SCP reduced lung index in PF rats in a dose-dependent manner. SCP significantly reduced IL-1β, IL-6, TNF-α,α-SMA and VIM expression levels in lung tissue (P
Affiliation
Jianfu Wu
External References
- PubMed ID:
- 38018265
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.