Investigation of anticancer effects of Boswellia serrata extract in combination with SN-38 on U373 GBM cells.
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Abstract
PURPOSE: Glioblastoma (GBM) is an aggressive brain tumor with limited treatment efficacy due to systemic toxicity and therapeutic resistance. This study aimed to evaluate the combined anticancer effects of SN-38, a potent chemotherapeutic agent, and Boswellia serrata, known for its boswellic acid content with apoptosis-inducing properties, on the U373 GBM cell line. METHODS: Human U373 GBM cells were treated for 24 h with control, SN-38 alone (10 µg/ml), Boswellia serrata alone (10, 25, 50 µg/ml), and their various combinations. Cell viability (MTT), total antioxidant status (TAS), total oxidant status (TOS), pro-apoptotic BAX, anti-apoptotic BCL-2, and STAT3 protein levels were analyzed using ELISA. Statistical significance was set at p
Affiliation
Numan Taspi̇nar
External References
- PubMed ID:
- 42423823
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