Lactiplantibacillus plantarum fermented hemp (Cannabis sativa) seeds modulate the gut microbiota and metabolic pathways to alleviate autoimmune inflammation.
fermented hemp () seeds modulate the gut microbiota and metabolic pathways to alleviate autoimmune inflammation in collagen-induced arthritis mice.
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Key Findings
Abstract
Rheumatoid arthritis (RA) is a debilitating autoimmune disease that severely affects patients' quality of life. Growing evidence links the gut microbiota, metabolism, and immune regulation to RA, driving interest in gut-targeted therapies. This study evaluates the therapeutic potential of-fermented hemp seeds (FHS) in collagen-induced arthritis (CIA) mouse models. FHS intervention significantly reduced joint swelling, cartilage and synovial damage, and systemic inflammation while restoring mobility and balancing CD4T cell differentiation. Compared toalone, FHS demonstrated superior efficacy. Additionally, FHS modulated RA-associated gut bacteria, including,,,, and, while restoring RA-suppressed species like,,,, and. FHS also influenced key metabolites, such as short-chain fatty acids, stearic acid, oleic acid, taurine, palmitic acid, docosahexaenoic acid, linoleic acid, and L-tyrosine, impacting metabolic pathways linked to RA progression. Notably, indolelactic acid, homovanillic acid, and bioactive peptides in FHS were absorbed into the bloodstream, exerting direct anti-inflammatory effects. These findings underscore FHS's potential as a therapeutic functional ingredient for RA, offering insights into its mechanisms through gut microbiota modulation and metabolic regulation.
Affiliation
Lingyue Shan
External References
- PubMed ID:
- 41017416
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