Lactobacillus salivarius MZ27 enhances the host's resistance to DSS.
MZ27 enhances the host's resistance to DSS by modulating the gut microbiota and the AHR/GPX4 signaling pathway.
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Key Findings
Abstract
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose pathogenesis is related to dysbiosis and impaired immunity. Probiotics play an important role in alleviating IBD. This study aimed to investigate howMZ27, isolated from disease-resistant Min pigs (a native Chinese pig breed), improved piglet colitisaryl hydrocarbon receptor/glutathione peroxidase 4 (AHR/GPX4) signaling. We induced piglet colitis using dextran sulfate sodium (DSS), and the piglets were separated into the following four groups: CON, LAB, DSS, and DSS + LAB. The results showed that MZ27 can significantly alleviate diarrhea, bloody stools, and weight loss, reduce the content of myeloperoxidase (MPO) and D-lactate in colon tissue, increase colon length, and reduce goblet cell loss. Mechanistically, MZ27 can promote the production of indole-3-lactic acid (ILA) and short-chain fatty acids (SCFAs). This change may be associated with the increased relative abundance ofand; additionally, MZ27 can improve intestinal barrier function by regulating the expression of AHR and its downstream signaling pathways. Moreover, MZ27 inhibited ferroptosis by promoting GPX4 expression through AHR-mediated cystine-glutamate transporter (xCT) and toll-like receptor 4/acyl-CoA synthetase 4 (TLR4/ACSL4) signals, thereby reducing the release of inflammatory cytokines to alleviate colonic inflammation. In conclusion, MZ27 improves colitis through host-microbiota interactions, indicating its potential as a probiotic candidate to support recovery from ongoing colitis.
Affiliation
Yusong Zheng
External References
- PubMed ID:
- 41294046
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