Licorice extract gel exhibits promising antimicrobial activity against S. mutans.
The Antimicrobial Effects of Licorice Extract against Streptococcus mutans as a Potential Oral Gel against Dental Caries.
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Abstract
INTRODUCTION: Dental caries is a prevalent chronic infectious disease primarily associated with Streptococcus mutans. Natural compounds with antimicrobial properties, such as licorice (Glycyrrhiza glabra), offer promising alternatives for oral health care. METHODS: Licorice roots were authenticated by a botanist and processed into an extract. The extract was formulated into an oral gel (100μg/mL) and sterilized using gamma irradiation. The minimum inhibitory concentration (MIC) of the gel against S. mutans was determined by the agar dilution method. Sub-MIC concentrations were used in a time-kill assay to assess antibacterial efficacy. A reduction of≥3 log10 CFU/mL was considered indicative of antibacterial activity. Data were ana-lyzed using the Shapiro-Wilk test, Kruskal-Wallis, and Tukey's post hoc test (SPSS v25, p
Affiliation
Hemad Iraji Khosrowshahi
External References
- PubMed ID:
- 40968420
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