Research Abstract
In Vitro Study
Lucidumones L-P: Meroterpenoids from Ganoderma lucidum and their inhibitory effect on triple negative breast cancer.
Jiao-Jiao Zhang, Ze-Hong Wu, Yuan-Nan Yuan, Dan Cai, Jia-Wang Liu, Hong Zhou, Zhong-Hui Yang, Yan-Jiao Yin, Yong-Xian Cheng
Phytochemistry
Aug 31, 2026
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Abstract
Meroterpenoids in Ganoderma mushrooms have attracted attention in recent years. In this effort, lucidumones L-P (1-5), five undescribed meroterpenoids, including four without chirality (1-4) and a pair of enantiomers (5), were isolated from G. lucidum. Their structures were elucidated using spectroscopic and computational methods. Compound 1 was structurally characterized as a decarbonized dimeric meroterpenoid. Compounds 2 and 3 possess significant inhibitory effects on the cell migration of MDA-MB-231 cells, and compound 2 inhibits the cell migration dose-dependently.
Affiliation
Jiao-Jiao Zhang
External References
- PubMed ID:
- 42002126
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