Mangiferin potentiates the activity of antifungal agents against fluconazole-resistant Candida.
Mangiferin potentiates the activity of antifungal agents against fluconazole-resistantspp.
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Key Findings
Abstract
To evaluate the antifungal activity of mangiferin againstspp. resistant to fluconazole.The antifungal activity of mangiferin was assessed using broth microdilution and its interaction with azoles and amphotericin B was evaluated by checkerboard. The activity of mangiferin againstspp. biofilms was assessed using the MTT colorimetric assay and its possible mechanism of action was evaluated using flow cytometry.Mangiferin showed activity againstandresistant to fluconazole and showed synergism with azoles and amphotericin B. Mangiferin increased the activity of antifungals againstbiofilms and caused depolarization of the mitochondrial membrane and externalization of phosphatidylserine, suggesting apoptosis.mangiferin combined with antifungals has potential againstspp.
Affiliation
Thais Lima Ferreira
External References
- PubMed ID:
- 39012219
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