Melatonin prorduction dysfunctions is associated with the progression of idiopathic scoliosis.
Melatonin. A possible role in pathogenesis of adolescent idiopathic scoliosis.
AI Summary
Key Findings
Abstract
STUDY DESIGN: The serum melatonin levels during 24-hour periods were compared between patients with idiopathic and age-matched normal control subjects. OBJECTIVE: To find if the melatonin deficiency may have some role for progression or etiology of idiopathic scoliosis in humans. SUMMARY OF BACKGROUND DATA: Experimentally induced scoliosis in chicken by pinealectomy can be attributed to the defect in melatonin metabolism. METHOD: Blood samples were correlated every 3 hours during 24-hour periods, and serum melatonin levels were measured and statistically analyzed. RESULTS: The level of melatonin, integrated concentration through 24 hours and night time (0:00 am-6:00 am), in the patients who had progressive curve (more than 10 degrees of progression in the previous 12 months) was significantly lower than the level in the patients who had a stable curve (less than 10 degrees of progression in the previous 12 months) or in the control subjects (P
Affiliation
Department of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan.
External References
- PubMed ID:
- 8727188
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.