Methylsulfonylmethane significantly ameliorated pancreas and lung histopathological changes.
Protective effect of methylsulfonylmethane in caerulein-induced acute pancreatitis and associated lung injury in mice.
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Key Findings
Abstract
OBJECTIVES: In the present study, we have elaborated the anti-inflammatory mechanism of MSM through homing of CD34stem cells towards an inflamed region by regulating hydrogen sulfide (HS) in an in vivo model of caerulein-induced acute pancreatitis (AP) and associated lung injury. METHODS: Male Swiss mice were treated with hourly intraperitoneal injections of caerulein (50μg/kg) for 6 h. MSM (500 mg/kg) was administered intraperitoneally 1 h after the first caerulein injection (therapeutic). The serum amylase activity and myeloperoxidase (MPO) activity in lung and pancreas were measured. The levels of HS and interleukin (IL)-1β, cystathionine-γ-lyase (CSE) and CD34expressions in pancreas and lungs were determined by RT-PCR and ELISA. KEY FINDINGS: Methylsulfonylmethane significantly ameliorated pancreas and lung histopathological changes, decreased serum amylase, MPO activity and inhibited caerulein-induced IL-1β expression. Furthermore, MSM reduced caerulein-induced HS levels by alleviating the expression of CSE in pancreas and lungs and increased CD34 expression and inhibited nuclear factor (NF)-κB translocation in caerulein-induced AP and associated lung injury. CONCLUSIONS: These findings indicate that MSM can effectively reduce inflammatory responses and induce the homing of CD34cells to the injured tissues.
Affiliation
Ranjith Kumar Velusamy
External References
- PubMed ID:
- 29971769
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