Multi-component synergy of safflower (Carthamus tinctorius L.) against hypertension-dyslipidemia.
Multi-component synergy of safflower (Carthamus tinctorius L.) against hypertension-dyslipidemia: Network pharmacology and molecular docking study.
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Key Findings
Abstract
BACKGROUND: Hypertension and dyslipidemia are prevalent comorbidities that synergistically increase cardiovascular risk. This study aims to systematically investigate the multi-component therapeutic mechanisms of safflower (Carthamus tinctorius L.) against this comorbidity. METHODS: Disease-related targets for hypertension and dyslipidemia were retrieved from GeneCards, OMIM, and TTD databases. Active components of safflower were screened from TCMSP based on oral bioavailability (OB≥30 %) and drug-likeness (DL≥0.18). Intersection targets were analyzed via functional enrichment and protein-protein interaction (PPI) network. Molecular docking simulations validated binding affinities between key components and core targets using AutoDock Vina. RESULTS: Fifty-nine shared therapeutic targets were identified. Enrichment analysis highlighted critical pathways including the AGE-RAGE signaling pathway in diabetic complications, lipid and atherosclerosis, and TNF signaling pathway. PPI network analysis identified eight hub targets (ICAM1, ESR1, VCAM1, EGFR, TNF, IL2, PPARG, MMP9). Molecular docking predicted strong binding energies (
Affiliation
Xiao Hu
External References
- PubMed ID:
- 41391263
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