N-ethylmaleimide antagonizes stress-induced gastric ulcers in rats.
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Key Findings
Abstract
N-ethylmaleimide (NEM) 10 or 25 mg/kg b.wt, given s.c. 20 min beforehand, dose-dependently and significantly antagonizes the severity of gastric glandular ulcers produced by restraint at 4 degrees C (stress) for 2 h. These findings suggest that reduced activity of endogenous nonprotein sulfhydryl substances in gastric tissue does not worsen stress-induced ulceration in rat stomachs, unlike the deleterious effect its depletion is claimed to have on ethanol-evoked gastric mucosal damage. Thus, decreased SH activity appears not to play a role in the aetiology of mucosal ulcers due to stress.
Affiliation
Department of Pharmacology, Faculty of Medicine, University of Hong Kong.
External References
- PubMed ID:
- 2009933
- DOI:
- 10.1007/BF01958150
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