Nanoencapsulated cordyceps extract enhances collagen synthesis and skin cell regeneration through antioxidation and autophagy.
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Key Findings
Abstract
Oxidative stress from reactive oxygen species is the main cause of skin ageing. Cordycepin, a bioactive compound of, contains antioxidant activity. This study examined extracellular matrix, antioxidant effect, autophagy activity, and skin regeneration in human dermal fibroblasts (HDFs) under normal and oxidative stress conditions. Slow disintegration was used to create nano-encapsulated cordyceps extract. HDFs were cultured and treated with 1 M cordycepin, 1 M medium, 0.1 M cordyceps medium loaded nanoparticles (CMP), or 1 mM HO. HDFs' senescent phenotypes were assessed, including cell proliferation, ROS scavenging, collagen and elastin synthesis, antioxidant activity, and wound healing. CMP size averaged 184.5 ± 95.2 nm increased cell proliferation and reduced HO-induced ROS. Thus, HDFs treated for 48 h increased skin regeneration activity 2.76-fold by expressing extracellular matrix and rescuing HO-induced damaged cells. It was significant that this CMP inhibited HO-induced oxidative stress and induced autophagy to regenerate HDFs. The developed CMP could be used in cosmetics.
Affiliation
Nawapol Upatcha
External References
- PubMed ID:
- 36999274
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