A novel flavonoid from leaves of Crataegus pinnatifida Bge. var. major and its anti-inflammatory activity.
A novel flavonoid from leaves ofBge. var.and its anti-inflammatory activity.
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Key Findings
Abstract
A previously unreported flavone glycoside was obtained from the leaves ofvar.. Its structure was determined through extensive spectroscopic characterisation, including NMR techniques, along with ESI-MS analysis. The compound was identified as 5,7-dihydroxy-6-(3,4,5-trihydroxy-6-(((3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)-2-(4-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-4H-chromen-4-one, named pinnatichromen. Furthermore, the anti-inflammatory activity of pinnatichromen was evaluated, and the compound exhibited a significant inhibitory effect on IL-1production at a concentration of 20 μM.
Affiliation
Zheming Ying
External References
- PubMed ID:
- 42054581
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