Orange peel extract has chemopreventive properties against lesions in the mouse mammary gland.
Chemopreventive effects of orange peel extract (OPE). II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland.
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Key Findings
Abstract
Cancer chemoprevention via the ingestion of natural substances is a current topic of considerable interest. Flavonoids are a family of biologically active phytochemicals having a variety of biological effects. Orange peel extract (OPE) is an abundant source of polymethoxyflavones (PMFs) with potential chemopreventive properties. The OPE used here was a mixture containing tangeretin (19.0%), heptamethoxyflavone (15.24%), tetramethoxyflavone (13.6%), nobiletin (12.49%), hexamethoxyflavone (11.06%), and sinensitin (9.16%). C57Bl/6 mice were fed a new "Western-style" diet (NWD), which had previously induced atypical hyperplasias in mammary gland, and NWD supplemented with a standardized OPE containing 30% PMFs. Mice were fed one of four diets: (1) AIN-76A diet (control); (2) NWD; 0.25% OPE in NWD; or (4) 0.5% OPE in NWD. After 3 months of feeding, atypical hyperplasias developed in mammary glands of mice fed NWD, but not in controls. After feeding OPE in NWD, atypical hyperplasias per mouse decreased in frequency compared to feeding NWD alone (P
Affiliation
Strang Cancer Prevention Center at The Rockefeller University, New York, New York 10021, USA.
External References
- PubMed ID:
- 17472462
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