[Patterns in the body's immune response to administration of El Tor vibrio cholera toxin to experimental animals].

Abstract

A study was made of some regularities attending the mechanisms of antibody production in the organism of experimental animals after the administration of El Tor cholera vibrio toxin. As revealed, the indices of the immune response depended on the chosen model, the method of its determination, the method of administration and the amount of the toxin administered. Dynamics of the primary and secondary responses of the immunocompetent cells of mouse spleen was determined. With the action of the El Tor toxin on the lymphoid tissue of mice there were expressed the general biological regularities of the response -- the optimal amount of the antigen-antibody complexes caused activation of the antibody-producing cells; high doses depressed the most reactive immunocompetent Y-cells. Apparently, there existed a genetic determinination of the immune response of the organism to a definite antigen -- the toxin of the El Tor cholera vibrio. It is supposed that it is necessary to choose groups which mostly require cholera vaccination.