Pecan pericarp extract protects against carbon tetrachloride-induced liver injury through oxidative mechanism.
Pecan pericarp extract protects against carbon tetrachloride-induced liver injury through oxidative mechanism in rats.
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Abstract
The purpose of this study was to quantify the proanthocyanidin content of pecan () pericarp extract (PPE) and to assess its useful impacts against carbon tetrachloride (CCl)-induced hepatotoxicity. Rats were randomly divided into four groups: Group 1: received intraperitoneal injection of saline solution, Group 2: was injected with PPE (25 mg/kg body weight) for 10 consecutive days, Group 3: received CCl(0.5 ml/kg, subcutaneous injection), Group 4: was coadministred with PPE + CCl. The CClwas administered every 3 days during 10 days. Results revealed the presence of a high amount of total proanthocyanidins in the PPE (81.01 ± 0.21 mg TAE.gDW). CClinjection induced significant reductions in hepatic antioxidants but increased hepatic lipid peroxidation (LPO) as well as serum injury biomarkers. However, cotreatment with PPE significantly (
Affiliation
Hallegue Dorsaf
External References
- PubMed ID:
- 33178425
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