Petroselinum crispum essential oil as promising source of bioactive compounds, antioxidant, antimicrobial activities.

Lessential oil as promising source of bioactive compounds, antioxidant, antimicrobial activitiesandpredictions.

Ghizlane Nouioura, Mohamed El Fadili, Naoufal El Hachlafi, Hatem A Abuelizz, Ahmed Elfallaki Elidrissi, Mohamed Ferioun, Najoua Soulo, Sara Er-Rahmani, Badiaâ Lyoussi, Elhoussine Derwich

Heliyon

Apr 29, 2024

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Abstract

This exploratory study aims to identify the volatile compounds in PC-Eo (L. essential oil) and evaluate its antioxidant and antimicrobial properties. Molecular docking, drug-likeness prediction, and pharmacokinetics (absorption, distribution, metabolism, excretion, and toxicity-ADMET) were among thesimulations that were used to explain the biological properties observed. For PC-Eo's chemical screening, gas chromatography-mass spectrophotometry (GC-MS) was employed. The antioxidant activity of PC-Eo was evaluated using fivecomplementary techniques, including 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radical scavenging activity,β-Carotene bleaching test (BCBT), reducing power (RP), and phosphomolybdenum assay (TAC). GC-MS analysis revealed that the primary components of PC-Eo are apiol (49.05 %), Myristicin (21.01 %), and 1-allyl-2,3,4,5-tetramethoxybenzene (13.14 %). The results of theantioxidant assays indicate that PC-Eo exhibits a superior antioxidant profile. Theantimicrobial activity of PC-Eo was assessed against five strains, including 2 g-positive bacteria, 2 g-negative bacteria, and one fungal strain (). The disc-diffusion assay revealed significant antibacterial and antifungal activities against all strains, with zones of inhibition exceeding 15 mm. The microdilution test highlighted the lowest MIC and MBC values with gram-positive bacteria, ranging from 0.25 to 0.5 % v/v for MIC and 0.5-1.0 % v/v for MBC. For the fungal strain, MIC was recorded at 1.25 % and MFC at 2.5 % v/v. PC-Eo demonstrates bactericidal and fungicidal activity based on the MBC/MIC and MFC/MIC ratios. According to the ADMET study, the primary PC-Eo compounds have advantageous pharmacokinetic characteristics. These findings provide empirical support for the traditional uses of this plant and indicate its possible use as a natural remedy.