Phyllanthin mitigates doxorubicin-induced acute cardiotoxicity.
Phyllanthin mitigates doxorubicin-induced acute cardiotoxicity: role of Bax/Bcl2 and Caspase-3 regulation.
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Key Findings
Abstract
Doxorubicin (DOX)-induced toxicity impairs cardiovascular functions.exhibits anti-inflammatory, antiviral, anticancer, antioxidant, nephroprotective, and hepatoprotective effects. However, its potential against DOX-induced acute cardiotoxicity is lacking. This study aimed to assess the underlying mechanism of action ofagainst DOX-induced acute cardiotoxicity in Sprague-Dawley rats. Phyllanthin was isolated from the methanolic extract of the aerial parts ofand characterized using HPLC-ESI-MS/MS. Its cardioprotective efficacy was evaluated in DOX-intoxicated male Sprague-Dawley rats (200-230 g) at doses of 50, 100, and 200 mg/kg, p.o., by examining electrocardiographic, hemodynamic, histological, and biochemical parameters. In the results, spectral analysis revealed that the isolated phyllanthin has a molecular formula of CHOand a molecular weight of 418.1534 Da.(50 and 100 mg/kg) effectively (
Affiliation
Xumei He
External References
- PubMed ID:
- 41287842
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