Policosanol alleviates chronic stress-induced growth impairment.
Policosanol alleviates chronic stress-induced growth impairment via gut microbiota-metabolite interactions: insights from 16S rRNA sequencing and LC-MS metabolomics.
AI Summary
Key Findings
Abstract
BACKGROUND/OBJECTIVES: Policosanol, a bioactive compound derived from rice bran wax, has demonstrated potential for alleviating stress, yet its underlying mechanisms remain elusive. This study aimed to elucidate its role in mitigating chronic stress-induced growth impairment and to explore its interactions with the gut microbiota and metabolomics. METHODS: Male rats were subjected to a 4-week chronic restraint stress protocol with or without policosanol supplementation (2 mg/kg/day). Systemic responses were evaluated by measuring growth parameters (including weight gain and muscle mass), serum biomarkers [cortisol and catecholamines (CA)], 16S rRNA sequencing (for cecal microbiota analysis), and LC-MS metabolomics (for cecal metabolite profiling). RESULTS: Stress induced a significant reduction in weight gain (-11.0%,
Affiliation
Ruxia Wang
External References
- PubMed ID:
- 41561167
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.