Polymeric film containing pomegranate peel extract as a promising tool for the treatment of candidiasis.

Gabriela S M Paula, Nicola Costa, T M S Silva, Kamila Arêas Bastos, Mariana Drummond Costa Ignacchiti, J A Severi, Rodrigo Lambert Oréfice, Lílian Gasparelli Carreira, Janaina Cecília Oliveira Villanova, Juliana Alves Resende

Nat Prod Res

Apr 17, 2022

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Abstract

Polymeric films containing pomegranate peel extract (PPE) can act as a drug-delivery platform for topical treatment of candidiasis. The composition, mechanical resistance, andantifungal activity of a polymeric film containing PPE at 1.25 mg.mLwere investigated. Films were prepared using a solvent casting technique. The incorporation of PPE in the polymeric matrix gave rise to homogeneous, smooth, shiny, and yellowish-brown films. FTIR spectra of the film containing PPE showed differences without compromising the stability of the extract and the matrix. SEM analysis showed the existence of interruptions in the continuity of the films with extract, which promoted a reduction in the mechanical parameters without significantly changing the tensile strength and elongation at break. Films showed adequate mechanical properties and antifungal activity against,,and.