Post-transcriptional regulation of RNA polymerase II levels in Caenorhabditis elegans.
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Key Findings
Abstract
To investigate the regulation of RNA polymerase II levels in Caenorhabditis elegans, we have constructed nematode strains having one, two, or three copies of ama-1, the gene for the largest subunit of RNA polymerase II. Steady-state levels of RNA polymerase II polypeptides and solubilized enzyme activity are invariant with gene dosage, indicating regulatory compensation. However, steady-state levels of ama-1 mRNA are directly proportional to gene dosage. These results imply that RNA polymerase II levels in C. elegans are regulated post-transcriptionally.
Affiliation
Division of Biological Sciences University of Missouri-Columbia 65211.
External References
- PubMed ID:
- 8436272
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