Prenatal antibiotic treatment does not decrease group B streptococcus colonization at delivery.
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Key Findings
Abstract
OBJECTIVE: To evaluate whether an outpatient antibiotic regimen decreased group B streptococcal (GBS) colonization to preclude the use of intrapartum antibiotics. METHODS: A double-blind randomized controlled trial evaluating prenatal oral amoxicillin versus placebo with the primary outcome of GBS colonization at the time of labor. RESULTS: Of those patients receiving both amoxicillin and a repeat culture at the time of labor, 6 of the 14 (43%) tested positive for GBS colonization. Given persistent GBS colonization of 67% (10/15) in the placebo group, treatment with amoxicillin did not significantly impact colonization at the time of delivery (P=0.20). CONCLUSION: A regimen of outpatient amoxicillin was associated with persistent GBS colonization in 43% of women at the time of labor. Oral prenatal antibiotic prophylaxis against GBS does not sufficiently reduce colonization to preclude intrapartum intravenous antibiotics.
Affiliation
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, IL, USA. [email protected]
External References
- PubMed ID:
- 18082163
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