Prognostic factors in vagus nerve stimulation for drug-resistant epilepsy.
Prognostic factors in vagus nerve stimulation for drug-resistant epilepsy. Results from a systematic review and meta-analysis of the literature.
AI Summary
Key Findings
Abstract
The aim of the present study was to conduct a systematic review and meta-analysis evaluating prognostic factors of response to treatment with VNS implantation in patients with drug-resistant epilepsy. We conducted a systematic review following the PRISMA 2020 guidelines to critically analyze relevant studies. The review question was formulated using the PICO framework: "In patients with drug-resistant epilepsy (P) undergoing VNS implantation (I) and subjected to preoperative and postoperative clinical and instrumental evaluations (C), can prognostic factors for therapeutic response (O) be identified?". As outcome variables for metanalysis evaluation, gender, age at epilepsy onset, age at VNS implantation, focal onset of seizures, epilepsy duration and genetic etiology were evaluated. The protocol for this systematic review and meta-analysis was registered in the PROSPERO database (registration number: CRD420261333961). The literature search yielded a total of 900 results. After removing duplicates, 571 papers were screened. Ultimately 39 were deemed relevant. There was a statistically significant association between focal seizures and VNS response (RR 1.31, 95% CI 1.02-1.69, p
Affiliation
Renata Martinelli
External References
- PubMed ID:
- 42307795
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.