Protective effects of L-theanine against bisphenol A-induced oxidative stress and gut microbiota disruption.
Protective effects of L-theanine against bisphenol A-induced oxidative stress and gut microbiota disruption in Wistar rats.
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Abstract
BACKGROUND: Gut microbiota homeostasis plays a central role in maintaining intestinal redox balance and immune regulation. Bisphenol A (BPA), a widely distributed environmental contaminant, has been associated with oxidative stress, inflammatory responses, and disturbances in intestinal microbial communities. L-theanine (LTN), a bioactive amino acid naturally present in green tea, possesses well-documented antioxidant and anti-inflammatory properties; however, its potential protective role against BPA-induced intestinal injury has not been fully clarified. METHODS AND RESULTS: In the present study, female Wistar albino rats were randomly allocated into three groups: control, BPA (50 mg/kg/day), and BPA + LTN (100 mg/kg/day) and treated for 30 days. Oxidative stress and inflammatory responses in intestinal and colonic tissues were assessed by measuring malondialdehyde (MDA), reduced glutathione (GSH) levels and myeloperoxidase (MPO), catalase (CAT) activities. BPA exposure significantly increased MDA (p
Affiliation
Mahdi Marzi
External References
- PubMed ID:
- 42142192
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