Protective effects of sinomenine against ankylosing spondylitis.
Protective Effects of Sinomenine Against Ankylosing Spondylitis and the Underlying Molecular Mechanisms.
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Key Findings
Abstract
BACKGROUND This study aimed to investigate the effect and underlying molecular mechanism of sinomenine (SIN) on ankylosing spondylitis (AS). MATERIAL AND METHODS To study the potential role of SIN in the pathogenesis of AS, an AS mouse model was established and mice were treated with different concentrations of SIN (10, 30, and 50 mg/kg, administered intraperitoneally). Markers of inflammation and oxidative stress were determined by ELISA assay. Western blot analysis and qRT-PCR were used to quantify the levels of related proteins and gene mRNA expression. RESULTS The results suggest that AS mice has higher levels of TNF-α, IL-1β, and IL-6 (p
Affiliation
Bo Dong
External References
- PubMed ID:
- 29849019
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