Rapid brain nicotine uptake from electronic cigarettes.
Rapid Brain Nicotine Uptake from Electronic Cigarettes.
AI Summary
Key Findings
Abstract
This study sought to determine brain nicotine kinetics from the use of increasingly popular electronic cigarettes (E-cigs).Brain uptake of nicotine following inhalation from E-cigs was directly assessed in 17 E-cig users (8 females), usingC-nicotine and positron emission tomography. The brain nicotine kinetics parameters from E-cigs were compared with those from smoking combustible cigarettes (C-cigs).After inhalation of a single puff of E-cig vapor, brain nicotine concentration rose quickly (mean T1/2 27 sec) with a peak amplitude 25% higher in females than males, resembling previous observations with C-cigs. Nonetheless, brain nicotine accumulation from E-cigs was smaller than that from C-cigs in both males and females (24% and 32%, respectively).E-cigs can deliver nicotine rapidly to the brain. Therefore, to the extent that rapid brain uptake promotes smoking reward, e-cigarettes might maintain a degree of nicotine dependence and also serve as non-combustible substitutes for cigarettes.
Affiliation
Kiran Kumar Solingapuram Sai
External References
- PubMed ID:
- 31676729
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.