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Reactions between nucleosides and platinum dimethylsulfoxide complexes.

Research Abstract

Reactions between nucleosides and platinum dimethylsulfoxide complexes.

Kong PC, Iyamuremye D, Rochon FD

Bioinorganic chemistry

Jan 1, 1976

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Abstract

Nucleosides (Nuc) react with cis-[Pt(DMSO)2Cl2] in dimethysulfoxide (DMSO) solution, to produce trans-[Pt(DMSO)(Nuc)Cl2], which then isomerize to cis-[Pt(DMSO)(Nuc)Cl2]. They also displace chlorine from K[Pt(DMSO)Cl3] in water to form trans-[Pt(DMSO)(Nuc)Cl2]. K[Pt(inosine)Cl3] and DMSO give in water cis-[Pt(DMSO)(Inosine)Cl2]. The configuration assignment of the compounds was based on chemical reactions, NMR techniques, analytical results, conductivity measurements and comparison with pyridine analogues. Chemical shifts in NMR and coupling constants of the aromatic protons of the nucleosides with 195Pt were used for the assignment of the binding sites of the nucleosides.

External References

PubMed ID:: 953048
DOI:: 10.1016/s0006-3061(00)80052-6
Source:: https://pubmed.ncbi.nlm.nih.gov/953048/

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