The results of this research suggest that natural extracts of E. cardamomum and C. longa possess anti-inflammatory effects.
Benefits of Cardamom ((L.) Maton) and Turmeric (L.) Extracts for Their Applications as Natural Anti-Inflammatory Adjuvants.
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Key Findings
Abstract
The genushas been widely used for phytotherapeutic purposes in traditional medicine throughout the world for its anti-inflammatory activity. Experimental studies have established that inflammation caused by chronic infections represents a risk factor for different forms of cancer. The objective of this study was focused on determining the anti-inflammatory capacity and cytotoxic activity of aqueous extracts of(cardamom) and(turmeric). The extracts were obtained by maceration and, through GC-MS/MS, a total of 11 different chemical components were determined in the aqueous extract of cardamom and 7 in the extract of turmeric. The main compounds found in cardamom and turmeric were-terpinyl acetate (54.46%) and-turmerone (33.45%), respectively. RT-qPCR results showed significantly lower gene expression levels of innate inflammatory cytokines (IL-6 and TNF-) compared to the control (LPS). Also, it was observed that the extracts do not possess cytotoxic activity against different cell lines, whereshowed EC(µg/mL) of 473.84 (HeLa cells), 237.36 (J774A.1 cells), 257.51 (Vero E6 cells), and 431.16 (Balb/C peritoneal cells) andshowed EC(µg/mL) of 351.17 (HeLa cells), 430.96 (J774A.1 cells), 396.24 (Vero E6 cells), and 362.86 (Balb/C peritoneal cells). The results of this research suggest that natural extracts ofandpossess anti-inflammatory effects and no cytotoxic activity against HeLa, J774A.1, Vero E6, and Balb/C peritoneal cell lines. Finally, it was observed that the extracts also decreased nitric oxide (NO) production in peritoneal macrophages.
Affiliation
Gustavo R Cárdenas Garza
External References
- PubMed ID:
- 34579443
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