Research Abstract
[Reversal of the pressor effect of PGF2alpha in the rat (author's transl)].
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Key Findings
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Abstract
In normal rats, prostaglandin F2alpha is a potent vasoconstrictor. The corresponding systemic hypertension is progressively attenuated by tachyphylaxis, revealing a longlasting fall of blood pressure. Tachyphylaxis is accelerated by previous injection of arachidonic acid and bradyskinin. The vasodepressive activity of PGF2alpha is inhibited by indomethacin.
External References
- PubMed ID:
- 950019
- DOI:
- 10.1007/BF01919855
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