Rhodiola rosea L., with its natural small molecule compounds like rosavin may be potential candidates for the treatment of AD.
Rosavin and salidroside attenuate microglia injury via nuclear factorκ-B signaling pathway.
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Key Findings
Abstract
OBJECTIVES: Inflammation, oxidative harm, and degradation of mitochondria ultimately contribute to the initiation neurodegenerative changes. This study investigated the inhibitory effects of rosavin and salidroside on neuroinflammation induced byβ-amyloid oligomers using primary microglia derived from the cerebral tissue of C57BL/6 J mice. KEY FINDINGS: Followingβ-amyloid oligomers' production, a series of continuous neurological deterioration takes place. Rosavin and salidroside exhibited distinct inhibitory effects on different neurodegenerative damage. Subsequent studies indicated that the protective mechanism of rosavin was associated with nuclear factorк-B phosphorylation. LAY SUMMARY: Rhodiola rosea L., with its natural small molecule compounds like rosavin may be potential candidates for the treatment of AD.
Affiliation
Hang Liu
External References
- PubMed ID:
- 41042989
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