Research Abstract
[Role of the endocrine function of the islands of Langerhans in the mechanism of development of hypothalamic obesity].
Lazaris IaA, Kasatkin IuN, Gol'dberg RS, Smirnova LK
Biulleten' eksperimental'noi biologii i meditsiny
Oct 1, 1976
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Abstract
Administration of alloxan to rats which developed hypothalamic adiposity damaged the pancreatic beta-cells and reduced the insulin secretion, thus arresting further weight gain despite some excess in food ingestion. A conclusion was drawn that in injury of the ventro-medial nuclei of the hypothalamus the most significant mechanism of obesity development was insulin hypersecretion induced by this action.
External References
- PubMed ID:
- 800955
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