Research Abstract
Signal input for a chemotactic response in the cellular slime mold Dictyostelium discoideum.
Mato JM, Losada A, Nanjundiah V, Konijn TM
Proceedings of the National Academy of Sciences of the United States of America
Dec 1, 1975
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Abstract
Drops with different concentrations of 3':5'-cyclic AMP were deposited at various distances from small populations of Dictyostelium discoideum amoebae, and the distances over which 50% of the amoebae drops reacted positively were determined. The linear regression analysis of a bouble logarithmic plot of distance against concentration gives a straight line with a slope of 1/4.25, which value suggests that the amoebae respond to a spatial gradient of cyclic AMP concentration. The threshold value for the signal is 3.6 X 10(-9) M/mm with a sensitivity of measurement of about 1%. These findings are discussed in relation to our present knowledge of cyclic AMP receptors.
External References
- PubMed ID:
- 174088
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