Terminalia catappa aqueous extract reduces hyperglycaemia and oxidative stress in diabetic-hypercholesterolemic rats.
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Abstract
BACKGROUND: Terminalia catappa is an important medicinal plant. Plants from the genus Terminalia have been reported for antidiabetic effects. OBJECTIVE: To study effect of Terminalia catappa leaves aqueous extract in type 2 diabetic rats. MATERIALS AND METHODS: High-fat diet (HFD) and a low dose of streptozotocin (35 mg/kg, i.p.) were used for inducing type 2 diabetes in rats; streptozotocin was injected after two weeks of dietary modification with HFD. HFD was continued throughout the study. Doses of 500 and 1000 mg/kg of aqueous extract of Terminalia catappa were used as a treatment for six weeks. At the end of the study, biochemical and oxidative stress parameters were estimated. Histopathology and immunohistochemistry of pancreatic tissue were performed. RESULTS: Significant decrease (p
Affiliation
Ojaskumar D Agrawal
External References
- PubMed ID:
- 39827649
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