Terminalia chebula fruit extracts inhibit bacterial triggers of some autoimmune diseases and potentiate the activity of tetracycline.
Retz. Fruit Extracts Inhibit Bacterial Triggers of Some Autoimmune Diseases and Potentiate the Activity of Tetracycline.
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Key Findings
Abstract
Retz. is a northern Indian plant species known for its anti-inflammatory and antimicrobial properties.fruit powder was extracted with solvents of varying polarity and screened for bacterial growth inhibition by disc diffusion assay. The minimum inhibitory concentration (MIC) was quantified by both liquid dilution and disc diffusion techniques. To screen for combinatorial effects, thefruit extracts were combined with a range of conventional antibiotics and tested against each bacteria using a liquid dilution assay. Where synergy was detected, the optimal ratios were determined using isobologram analysis. Toxicity was examined usingnauplii and HDF bioassays.fruit methanolic, aqueous and ethyl acetate extracts displayed strong antimicrobial activity against the bacterial triggers of all autoimmune inflammatory diseases except, for which only moderate inhibition was observed. Indeed, MIC values as low as 195 μg/mL were measured for the aqueous extract against a resistant strain of. Of further note, both the aqueous and ethyl acetate extracts interacted synergistically in combination with tetracycline against(Σ FIC 0.38 and 0.25 respectively). All extracts were nontoxic in theand HDF toxicity assays, further indicating their potential for medicinal use.
Affiliation
Aaron Mandeville
External References
- PubMed ID:
- 30262960
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