Research Abstract
The effect of allopurinol on oxypurine excretion in xanthinuria.
Salti IS, Kattuah N, Alam S, Wehby V, Frayha R
The Journal of rheumatology
Jun 1, 1976
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Abstract
In a patient with xanthine urolithiasis secondary to hereditary xanthinuria (xanthine oxidase deficiency), allopurinol administration resulted in a 20 per cent increase in oxypurine excretion and an elevation of the urinary xanthine/hypoxanthine ratio from 4.08 to 6.53. The rise in this ratio suggests that residual xanthine oxidase activity may have been present. It is possible that the excessive re-utilization of hypoxanthine and xanthine in this disease prevents the allopurinol-induced inhibition of de novo purine biosynthesis that is seen in normal subjects.
External References
- PubMed ID:
- 950637
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