Research Abstract
The effects of antipyretics on metabolic processes in rat liver mitochondria. Part II. The action of sodium salicylate, and pyrazolones on oxidation of alpha-ketoglutarate.
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Abstract
The effect of sodium salicylate (SS), phenazone (Ph), and amiphenazone (APh) on the uptake of alpha-ketoglutarate (alpha-KG) by the rat liver mitochondria was studied in vitro. The investigated antipyretics inhibited the uptake of alpha-KG in the state 3 of respiration, and significantly increased it in state 4. This results and those of the preceding paper show that alpha-KG taken up by the mitochondrial preparations in respiratory state 4 is not utilized in the oxidative processes of the respiratory chain.
External References
- PubMed ID:
- 951304
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