Research Abstract
The metabolic effects of limbic leucotomy in Gilles de la Tourette syndrome.
Sawle GV, Lees AJ, Hymas NF, Brooks DJ, Frackowiak RS
Journal of neurology, neurosurgery, and psychiatry
Sep 1, 1993
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1 min read
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Abstract
Regional cerebral oxygen metabolism was measured before and after limbic leucotomy in a patient with Gilles de la Tourette syndrome, obsessive compulsive disorder, and obsessional slowness. The preoperative scan showed hypermetabolism in the caudate nuclei, which normalised after operation. It is proposed that the beneficial effects of this operation on both tics and obsessive compulsive behaviour are mediated by disruption of abnormal neural activity in basal ganglia-thalamocortical loops.
Affiliation
MRC Cyclotron Unit Clinical Sciences Section, Hammersmith Hospital, London.
External References
- PubMed ID:
- 8410025
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