Research Abstract
The synthesis of prostaglandin analogs containing the (hydroxycyclooctylidene)methyl ring system.
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Abstract
The synthesis of prostaglandin analogs incorporating the (2-hydroxycyclooctylidene)methyl moiety in place of the natural C13-C20 sidechain has been accomplished via copper-assisted conjugate addition of the (cyclooctylidene)methyllithium 5 to the cyclopentenone intermediates 7 and 10.
External References
- PubMed ID:
- 948627
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