Therapeutic effects of avocado seed powder against reproductive toxicity induced by Mancozeb.
Therapeutic effects of avocado (Mill.) seed powder against reproductive toxicity induced by Mancozeb (herbicide) in female rabbits.
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Abstract
Pesticides like Mancozeb are being increasingly indispensable in the control of crop pests. Unfortunately, they have been implicated in genotoxicity due to their ubiquity, toxicological properties, persistence and presence in the food chain. This study sought to evaluate the efficacy of powdered avocado seed on reproductive parameters in the management of oxidative stress in female rabbits caused by the herbicide Mancozeb. Twenty-eight female rabbits aged 7-8 months and weighing between 2780.4 g and 3143.7 g were randomly divided into four groups of seven rabbits each. Each group received for 90 consecutive days distilled water or Mancozeb associated or not with avocado seed powder orally as follows: T1: 10 ml distilled water; T2, T3 and T4: 100 mg/kg bw Mancozeb. This was followed by oral administration of 250, 500, and 0 mg/kg of avocado seed powder for T2, T3, and T4, respectively. Water and feed were distributedCollected data concerned growth, carcass and reproductive performances, hematological and biochemistry characteristics. Results demonstrated that pregnant and lactating female rabbits administered Mancozeb exhibited a significant decrease (
Affiliation
R B B Ayagirwe
External References
- PubMed ID:
- 37483832
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