These findings indicate that PE possesses anti-inflammatory and anti-atopic properties.
The Anti-atopic Perilla Seed Oil and Ethanol Extract on TNF-α/IFN-γ-Stimulated inflammatory Responses in Human HaCaT Keratinocytes.
AI Summary
Key Findings
Abstract
Chronic inflammatory atopic dermatitis (AD) is a skin disorder characterized by cutaneous inflammation and a dysfunctional skin barrier. Although perilla seed oil (PO) is known to exhibit various biological activities, including anti-cancer, anti-inflammatory, and anti-oxidant effects, its inhibitory effects together with the ethanol extract of PO (PE) on atopic and inflammatory responses in the dermal skin has not yet been investigated. In the present study, PE significantly reduced mRNA expressions of inflammation-associated cytokines such as tumor necrosis factor (TNF)-αand interleukin (IL)-1β, IL-6, IL-8, and IL-33. Furthermore, PE decreased the levels of the chemokine, thymus- and activation-regulated chemokine (TARC/CCL17) in TNF-αand interferon (IFN)-γ-stimulated human HaCaT keratinocytes. In addition, PE effectively suppressed activation of MAPK/NF-κB and JAK/STAT signaling pathways in HaCaT keratinocytes co-stimulated with TNF-αand IFN-γ. These findings indicate that PE possesses anti-inflammatory and anti-atopic properties, suggesting its potential benefits in treating inflammatory skin diseases including AD.
Affiliation
Hee-Jung Choi
External References
- PubMed ID:
- 41085638
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.