These results indicate that in cannabis smokers, men exhibit greater cannabis-induced analgesia relative to women.
Sex-dependent effects of cannabis-induced analgesia.
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Key Findings
Abstract
BACKGROUND: Preclinical studies demonstrate that cannabinoid-mediated antinociceptive effects vary according to sex; it is unknown if these findings extend to humans. METHODS: This retrospective analysis compared the analgesic, subjective and physiological effects of active cannabis (3.56-5.60% THC) and inactive cannabis (0.00% THC) in male (N=21) and female (N=21) cannabis smokers under double-blind, placebo-controlled conditions. Pain response was measured using the Cold-Pressor Test (CPT). Participants immersed their hand in cold water (4°C); times to report pain (pain sensitivity) and withdraw the hand (pain tolerance) were recorded. Subjective drug ratings were also measured. RESULTS: Among men, active cannabis significantly decreased pain sensitivity relative to inactive cannabis (p
Affiliation
Ziva D Cooper
External References
- PubMed ID:
- 27522535
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