Thymoquinone-coenzyme Q10 combination therapy ameliorates post-spinal cord injury osteoporosis.
Thymoquinone-Coenzyme Q10 Combination Therapy Ameliorates Post-Spinal Cord Injury Osteoporosis Through Enhanced Wnt/β-Catenin Signaling and Antioxidant Defense.
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Key Findings
Abstract
Spinal cord injury (SCI) results in rapid bone loss and osteoporosis development. This study investigated the synergistic effects of a combination of thymoquinone (TQ) and coenzyme Q10 (CoQ10) on SCI-induced osteoporosis. Thirty male Wistar rats underwent complete spinal cord transection at T10 and were divided into five groups: sham, untreated SCI, TQ-treated (100 mg/kg/day), CoQ10-treated (10 mg/kg/day), and combination therapy (TQ + CoQ10). After 21 days of treatment, combination therapy significantly improved BBB locomotor scores (12.1 ± 0.7 vs. 2.1±0.4 in untreated SCI; p
Affiliation
JiZu Tang
External References
- PubMed ID:
- 41742598
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