Vagus nerve stimulation reduces cutaneous inflammation and proinflammatory cytokines in murine models of psoriasis and atopic dermatitis.
Vagus Nerve Stimulation Reduces Cutaneous Inflammation and Proinflammatory Cytokines in Murine Models of Psoriasis and Atopic Dermatitis.
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Key Findings
Abstract
Vagus nerve stimulation (VNS) modulates systemic inflammation through the cholinergic anti-inflammatory pathway, but its effects on cutaneous inflammatory diseases remain unexplored. We investigated whether invasive VNS could reduce clinical inflammation and proinflammatory cytokines in murine models of psoriasis and atopic dermatitis (AD). C57BL/6 mice received imiquimod 5% cream to induce psoriasiform inflammation, while NC/Nga mice received 2,4-dinitrochlorobenzene (DNCB) to induce AD-like inflammation. Acute invasive VNS (5 Hz/5 ms for 5 min) or sham procedures were performed 6 or 24 h before sacrifice. Cutaneous cytokine levels were assessed by immunoblotting and immunofluorescence staining, while systemic inflammation was evaluated by analyzing splenic and plasma cytokines. VNS reduced TNF-αand IL-6 in imiquimod-treated skin at both 6- and 24-h post-stimulation (TNF-α/6 h: 63%, p
Affiliation
William J Nahm
External References
- PubMed ID:
- 42281200
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