Vitamins B depletion, lower iron status and decreased antioxidative defense has been observed in patients with chronic hepatitis C treated by pegylated interferon alfa and ribavirin.
Vitamins B depletion, lower iron status and decreased antioxidative defense in patients with chronic hepatitis C treated by pegylated interferon alfa and ribavirin.
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Key Findings
Abstract
BACKGROUND & AIMS: The impact of pegylated interferon combined with ribavirin upon the status of B vitamins, iron and oxidative stress in patients with hepatitis C virus (HCV) infection was examined. METHODS: Blood levels of B vitamins, iron status, and oxidative stress associated biomarkers were determined for 152 healthy controls and 109 HCV patients treated by pegylated interferon and ribavirin at three stages: before therapy, week 24 of treatment, and 48 weeks after therapy. RESULTS: HCV infection significantly lowered vitamin B(6) and folate (p
Affiliation
Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung City, Taiwan, ROC.
External References
- PubMed ID:
- 19042060
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