Whey protein concentrate as a tryptophan-based nutritional intervention for premenstrual dysphoric disorder.
Whey Protein Concentrate as a Tryptophan-Based Nutritional Intervention for Premenstrual Dysphoric Disorder (PMDD): A 3-Month Case Study.
AI Summary
Key Findings
Abstract
INTRODUCTION: Premenstrual dysphoric disorder (PMDD) is a hormone-sensitive mood disorder characterized by cyclical emotional and functional impairment in the luteal phase. Serotonergic dysregulation contributes to its pathophysiology. CASE PRESENTATION: A 38-year-old registered dietitian with clinically diagnosed PMDD consumed 5 tablespoons of whey protein concentrate (WPC) blended into a carbohydrate-rich smoothie daily for 8 days before menstruation, across 3 consecutive cycles. OUTCOMES: The subject perceived substantial symptom relief (~ 80-95%), compared to her prior cycles and years of consistent symptoms. No adverse effects were reported. DISCUSSION: WPC provides a food-based source of tryptophan; co-ingestion with carbohydrates enhances tryptophan transport into the brain by increasing the Trp/LNAA ratio. CONCLUSION: WPC may offer an effective and well-tolerated nutritional intervention for PMDD. Controlled trials are warranted.
Affiliation
Fay Kazzi
External References
- PubMed ID:
- 41586426
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