Xiaotan sanjie recipe inhibits the proliferation of gastric cancer cells.
Study on the mechanism of xiaotan sanjie recipe for inhibiting proliferation of gastric cancer cells.
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Key Findings
Abstract
OBJECTIVE: To explore the mechanism of Xiaotan Sanjie Recipe (XtSjR, Recipe for dissolving phlegm to eliminate stagnation) in inhibiting proliferation of gastric cancer cells. METHODS: The nude mouse human gastric cancer MKN-45 in situ transplantation tumor model was established by use of OB glue, and 40 model mice were randomized into 5 groups, model group, low-dose XtSjR group, middle-dose XtSjR group, high-dose XtSjR group, and 5-Fu group, 8 rats in each group. Human gastric cancer MKN-45 telomerase reverse transcriptase (hTERT) protein and mRNA expressions were assayed by immunohistochemical method and real-time fluorescence quantitative RT-PCR, and influences of XtSjR on the expressions of hTERT protein and mRNA were investigated in the nude mouse human gastric cancer MKN-45 in situ tumor transplantation model. RESULTS: 1) There were significant differences in the mean tumor weight between the low-, middle-, high-dose XtSjR groups and the model group (all P
Affiliation
No.211 Hospital of the Chinese People's Liberation Army, Harbin 150001, China.
External References
- PubMed ID:
- 21287780
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