Zinc chloride exposure results in developmental and reproductive toxicities.
Reproductive and developmental toxicities of zinc supplemented rats.
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Key Findings
Abstract
Reproductive and developmental toxicities of zinc supplementation in F(0) rats and F(1) progeny were examined. Rats were treated by gavaging with zinc chloride (ZnCl(2)) at 0.0, 7.5, 15 and 30mg/kg-d. ZnCl(2) treatment was associated with deficient energy imbalances, reduced number of live pups/litter, decreased live birth index, increased mortality and increased fetal resorption. Changes in serum clinical chemistry and hematologic parameters were sex-related. In F(0) females, ZnCl(2) was associated with increased liver/body weight ratios, reduced creatinine and reduced alkaline phosphatase concentrations. In F(0) males, ZnCl(2) significantly increased relative liver weight and elevatedγ-GGT. In addition, at birth, F(1) males exhibited, a significant (p
Affiliation
Department of Pharmacology and Toxicology and Neuroscience Program, B307 Life Sciences Building, Michigan State University, East Lansing, MI 48824, United States.
External References
- PubMed ID:
- 20977935
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