Research Abstracts - GreenMedInfo

In Vitro Study

Isoginkgetin inhibits non-small cell lung cancer by inducing oxidative stress and regulating M1 macrophage polarization.

Sep 12, 2026 Zhu C, Zhang F, Li X, Xing D, Cai H, Wang X, Qu H, Li L, Zheng X

Phytomedicine : international journal of phytotherapy and phytopharmacology

Ginkgo biloba, Flavonoids

Non-Small-Cell Lung Carcinoma

Antiproliferative, Anti-metastatic

View abstract

In Vitro Study

Isoginkgetin protects against degeneration of ALS motor neurons via regulating the GSK-3β-TFEB signaling axis.

Sep 12, 2026 Li A, Xiao X, Liu G, Li K, Ling Y, Deng S, Xu C, Cao SQ, Wen J, Lu G, Yang G, Fang EF, Qin D, Su H

Pharmacological research

Ginkgo biloba, Flavonoids

Amyotrophic Lateral Sclerosis

Neuroprotective Agents

View abstract

Animal Study

Isoginkgetin stabilizes atherosclerotic plaques by targeting NR4A2 to modulate the PPAR signaling pathway and reprogram ceramide metabolism, thereby inhibiting vascular smooth muscle cell phenotypic transformation.

Sep 12, 2026 Wei D, Zhong Z, Li H, Qi J, Liu Y, Cao H, Ma Y, Li Z, Yang G, Jiang Y, Zhang Z

International immunopharmacology

Ginkgo biloba, Flavonoids

Atherosclerosis

Anti-atherogenic

View abstract

Animal Study

Icariin alleviates ovariectomy-induced osteoporosis by promoting M2 macrophage polarization and suppressing osteoclast activation.

Sep 11, 2026 Yang Y, Luo C, Ren X, Tan Q, Deng C

Cytokine

Icariin

Osteoporosis

Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Matrix metalloproteinase-9 (MMP-9) inhibitor

View abstract

Animal Study

Icariin Alleviates Diabetes-Associated Cognitive Dysfunction Through Modulation of LCN2-MEK/ERK Signaling-Associated Neuroinflammation.

Sep 11, 2026 Jiao X, Ren Y, Yu Z, Zhou J, Wang D, Yan B, Tian G

CNS neuroscience & therapeutics

Icariin

Diabetes: Cognitive Dysfunction

Neuroprotective Agents

View abstract

Animal Study

Icariin Attenuates Neuroinflammation and Dopaminergic Degeneration in a Rodent Model of Parkinson's Disease by Promoting the Expansion of Regulatory T Cells.

Sep 11, 2026 Xu S, Jiang L, Zhang H, Zhang P, Pan Z

Frontiers in bioscience (Landmark edition)

Icariin

Parkinson's Disease

Anti-Inflammatory Agents, Neuroprotective Agents

View abstract

In Vitro Study

Icariin ameliorates gestational diabetes mellitus by targeting the S100A9-mediated RAGE pathway to activate mitophagy.

Sep 11, 2026 Yang J, Sun H, Wan Y, Wu Y

Placenta

Icariin

Gestational Diabetes

Antioxidants, Antiproliferative, Anti-Apoptotic

View abstract

Animal Study

Icariin alleviates triptolide-induced testicular vacuolization via modulating germline ferroptosis and blood-testis barrier integrity.

Sep 11, 2026 He L, Yang X, Wu T, Li Z, Zhao D, Fu Y, Chu Y, Dong J, Li J, Huang Q, Shen C, Wang C, Wang X, Qiao C, Wang X, Meng Q, Yu J, Sun F

Frontiers in cell and developmental biology

Icariin

Testicular Injury: Chemical/Metal Induced

View abstract

In Vitro Study

Icariin alleviates abdominal aortic aneurysm by targeting CYP1B1 to inhibit M1 polarization and VSMC apoptosis.

Sep 11, 2026 Liu X, Li S, Wang J, Tian Z

General physiology and biophysics

Icariin

Aortic Aneurysm

Anti-Inflammatory Agents, NF-kappaB Inhibitor, Anti-Apoptotic

View abstract

Animal Study

Icariin Induces Autophagy-dependent Apoptosis in FaDu Head and Neck Squamous Cell Carcinoma.

Sep 11, 2026 Kang KR, Kim DK, Lim H, Chun HS, Kim JS

Anticancer research

Icariin

Head and Neck Cancer

Apoptotic, Antiproliferative

View abstract

In Vitro Study

Investigating the phytochemical composition of Curcuma longa, Azadirachta indica, and Asparagus racemosus using network pharmacology and molecular docking approaches for ovarian cancer therapy.

Sep 10, 2026 Santoshi S, Tanwar A, Bahri R, Aggrawal N, Ganjewala D, Bansal H

Zeitschrift fur Naturforschung. C, Journal of biosciences

Asparagus, Neem, Turmeric

Ovarian Cancer

Immunomodulatory, Chemotherapeutic

View abstract

Animal Study

In vitro and in vivo evaluation of oleuropein loaded hyalurosomes for diabetic foot ulcer healing.

Sep 9, 2026 Elgendy AI, El-Gendy AO, Aboud HM, Abo El-Ela FI, Zanaty MI

Scientific reports

Oleuropein

Diabetic Ulcer, Foot Ulcer

Anti-Inflammatory Agents, Anti-Ulcer Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Interleukin-6 Downregulation, Interleukin-17 downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor

View abstract

In Vitro Study

Impact of cytosine and piperine on colorectal cancer progression based on Mendelian randomization and functional validation.

Aug 20, 2026 Su L, Peng Z, Prasai A, Nov P, Tan Y, Wang M

Discover oncology

Piperine

Colorectal Cancer

Chemopreventive, Antiproliferative

View abstract

Animal Study

Investigation of Thymoquinone's Effects on Bisphenol A-Induced Neurotoxicity, Keap-1/Nrf-2 Signalling, Oxidative Stress, and Behavior in Rats.

Aug 19, 2026 Kuzay Aksoy D, Tozak Yıldız H

Journal of visualized experiments : JoVE

Thymoquinone

Bisphenol Toxicity

Antioxidants, Neuroprotective Agents, Nrf2 activation, Bisphenol A

View abstract

In Vitro Study

Improved Chemosensitivity in Metastatic Castration-Resistant Prostate Cancer: The Synergistic Effects of S-Adenosylmethionine and Cabazitaxel.

Aug 14, 2026 Arpino R, Cadoni F, Pagano C, Coppola L, Del Vecchio V, Nigam A, Mosca L, Porcelli M

Cancer medicine

S-Adenosylmethionine (SAMe)

Prostate Cancer

Apoptotic, Chemosensitizer, Cell cycle arrest

View abstract

Animal Study

Investigating the Neuroprotective Effects of Saw Palmetto Fruit Extract Against D-Galactose and Aluminum Chloride Induced Alzheimer's Disease: In Vivo Study.

Aug 12, 2026 Nisar A, Akhter N, Chauhdary Z, Anjum F, Saleem F, Sana S, Rafiq I, Mustafa A

Neurochemical research

Saw Palmetto

Alzheimer's Disease, Aluminum Toxicity

Neuroprotective Agents, Aluminum Chloride

View abstract

Animal Study

Inhibition of MST1/2 attenuates the anti-hepatocarcinogenesis effect of Salvianolic acid B via the ERK/MAPK signaling pathway.

Aug 12, 2026 Li M, Xu J, Zhu L, Yang X, Ren H, Jiang J, Li L, Yang Y, Gong Y

European journal of pharmacology

Salvia miltiorrhiza

Liver Cancer

Chemopreventive

View abstract

In Vitro Study

Immune dysregulation and cellular dysfunction mediate di-n-pentyl phthalate-induced hepatotoxicity.

Jul 31, 2026 Yu Gan, Yongyi Luo, Xiandong Ye, Kaiyan Zhang, Zhenqiu Xia, Lei Yang, Chaoming Zhou, Gan Xie, Wenyan Zhong, Tengfei Yuan, Shuimiao Lin, Yuan Fang, Jian Wang, Beibei Liu, Weiwei Peng, Chuanhui Cao, Liting Zhong

Food Chem Toxicol

Chemically-Induced Liver Damage, Phthalate Toxicity

Phthalates

View abstract

In Vitro Study

Investigation of anticancer effects of Boswellia serrata extract in combination with SN-38 on U373 GBM cells.

Jul 8, 2026 Numan Taspi̇nar, Sidika Genc, Ali Taghizadehghalehjoughi, Esmanur Ni̇gde, Kubra Karabulut, Rahsan Ilikci Sagkan

Mol Biol Rep

Frankincense

Glioblastoma

Antioxidants, Apoptotic, Antiproliferative, Bcl-2 protein down-regulation

View abstract

Review

Icariin: Multi-target natural products for the multi-stage prevention and treatment of breast cancer (Review).

Jun 30, 2026 Yu Wen, Yunyan Chen, Lei Yang, Tingfen Wu, Qinghua Peng, Huiyan Xie, Xuemei Chen

Mol Clin Oncol

Icariin

Breast Cancer

Chemopreventive

View abstract

In Vitro Study

Icariin regulates acne pathophysiology and extracellular matrix protein synthesis.

Jun 30, 2026 Dong Hyo Kim, Ji Young Yoon, Jun Hyo Lee, Myeong-Woo Nam, Dae Hun Suh

Exp Dermatol

Icariin

Acne

Proliferative

View abstract

In Vitro Study

Inflammation-targeted nanoaggregates encapsulated triptolide and hyperoside for M2 macrophage repolarization and oxidative stress reversal in rheumatoid arthritis therapy.

Jun 30, 2026 Zhonghui Xue, Huijie Zhou, Jingru Cui, Yujie Chen, Xiaofang Li, Min Yan, Xiangxiang Wu, Huahui Zeng

Colloids Surf B Biointerfaces

Flavonoids, Triptolide

Inflammation, Rheumatoid Arthritis, Oxidative Stress

Anti-Inflammatory Agents, Antioxidants

View abstract

Animal Study

Icariin attenuates renal injury in streptozotocin-induced diabetic rats with and without adenine-induced chronic kidney disease.

Jun 21, 2026 Raya Al Maskari, Haytham Ali, Priyadarsini Manoj, Mohammed Al Za'abi

Pharmaceuticals (Basel)

Icariin

Diabetes Mellitus: Type 2, Chronic Kidney Disease (CKD)

Anti-Inflammatory Agents, Renoprotective

View abstract

In Vitro Study

Icariin promotes lysosomal degradation of amyloid-β precursor protein.

Jun 14, 2026 Cong Lin, Zhen Xu, Junwen Yan, Bo Liu, Fei Li

Brain Res Bull

Icariin

Alzheimer's Disease

Neuroprotective Agents

View abstract

Research Abstracts Database

Abstracts Starting with "I"

Isoginkgetin inhibits non-small cell lung cancer by inducing oxidative stress and regulating M1 macrophage polarization.

Isoginkgetin protects against degeneration of ALS motor neurons via regulating the GSK-3β-TFEB signaling axis.

Isoginkgetin stabilizes atherosclerotic plaques by targeting NR4A2 to modulate the PPAR signaling pathway and reprogram ceramide metabolism, thereby inhibiting vascular smooth muscle cell phenotypic transformation.

Icariin alleviates ovariectomy-induced osteoporosis by promoting M2 macrophage polarization and suppressing osteoclast activation.

Icariin Alleviates Diabetes-Associated Cognitive Dysfunction Through Modulation of LCN2-MEK/ERK Signaling-Associated Neuroinflammation.

Icariin Attenuates Neuroinflammation and Dopaminergic Degeneration in a Rodent Model of Parkinson's Disease by Promoting the Expansion of Regulatory T Cells.

Icariin ameliorates gestational diabetes mellitus by targeting the S100A9-mediated RAGE pathway to activate mitophagy.

Icariin alleviates triptolide-induced testicular vacuolization via modulating germline ferroptosis and blood-testis barrier integrity.

Icariin alleviates abdominal aortic aneurysm by targeting CYP1B1 to inhibit M1 polarization and VSMC apoptosis.

Icariin Induces Autophagy-dependent Apoptosis in FaDu Head and Neck Squamous Cell Carcinoma.

Investigating the phytochemical composition of Curcuma longa, Azadirachta indica, and Asparagus racemosus using network pharmacology and molecular docking approaches for ovarian cancer therapy.

In vitro and in vivo evaluation of oleuropein loaded hyalurosomes for diabetic foot ulcer healing.

Impact of cytosine and piperine on colorectal cancer progression based on Mendelian randomization and functional validation.

Investigation of Thymoquinone's Effects on Bisphenol A-Induced Neurotoxicity, Keap-1/Nrf-2 Signalling, Oxidative Stress, and Behavior in Rats.

Improved Chemosensitivity in Metastatic Castration-Resistant Prostate Cancer: The Synergistic Effects of S-Adenosylmethionine and Cabazitaxel.

Investigating the Neuroprotective Effects of Saw Palmetto Fruit Extract Against D-Galactose and Aluminum Chloride Induced Alzheimer's Disease: In Vivo Study.

Inhibition of MST1/2 attenuates the anti-hepatocarcinogenesis effect of Salvianolic acid B via the ERK/MAPK signaling pathway.

Immune dysregulation and cellular dysfunction mediate di-n-pentyl phthalate-induced hepatotoxicity.

Investigation of anticancer effects of Boswellia serrata extract in combination with SN-38 on U373 GBM cells.

Icariin: Multi-target natural products for the multi-stage prevention and treatment of breast cancer (Review).

Icariin regulates acne pathophysiology and extracellular matrix protein synthesis.

Inflammation-targeted nanoaggregates encapsulated triptolide and hyperoside for M2 macrophage repolarization and oxidative stress reversal in rheumatoid arthritis therapy.

Icariin attenuates renal injury in streptozotocin-induced diabetic rats with and without adenine-induced chronic kidney disease.

Icariin promotes lysosomal degradation of amyloid-β precursor protein.