Research Abstracts - GreenMedInfo

Animal Study

Oleuropein-based olive leaf extract enhances muscle mitochondrial bioenergetics response to moderate - but not maximal - intensity exercise in humans.

Sep 9, 2026 Lanfranchi C, Moreno-Asso A, Horstman AMH, Mistro S, Migliavacca E, Cominetti O, Stolte J, Métairon S, Hermant A, Pedersen AL, Dayon L, De Marchi U, Feige JN, Zanou N, Place N

The Journal of physiology

Olive leaf extract, Oleuropein

Athletic Performance

Anti-Inflammatory Agents, Exercise

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Human Study

Adjuvant treatment with an oleuropein-enriched olive leaf extract improves periodontal outcomes in older adults with periodontitis: Metabolomic insights from a randomized controlled trial.

Sep 9, 2026 Forbes-Hernández TY, Vargas-Corral FG, Bullón B, Rivas-García L, Lipari V, Giampieri F, Grosso G, Battino M, Bullón P, Quiles JL

Phytomedicine : international journal of phytotherapy and phytopharmacology

Olive leaf extract, Oleuropein

Periodontitis

Anti-Inflammatory Agents, Antioxidants

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Human Study

Health status, risk factors and effects of olive leaf extract infusion (Olea europaea L.) on blood pressure in a hypertensive population.

Sep 9, 2026 Affane F, Meskini Z, Araf A, Hadri Z, Naas H, Yssaad D

Roczniki Panstwowego Zakladu Higieny

Olive leaf extract

Hypertension

Antihypertensive Agents

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Animal Study

Hepatoprotective effect of Olea europaea L. leaf against oxidative stress in hepatocytes and zebrafish embryos.

Sep 9, 2026 Zhang X, Zhang C, Jiang T, Pei D, Qu Q

Natural product research

Olive leaf extract

Oxidative Stress, Liver Damage

Antioxidants, Hepatoprotective

View abstract

Animal Study

Apigenin Upregulates Regulatory B Cells, Suppresses Class Switch Recombination, and Restores Immune Homeostasis to Treat Autoimmune Arthritis and Sepsis.

Sep 9, 2026 Chen H, Huang Y, He Y, Zha M, Liu X, Lin T, Li L, He Z, Zheng SG, Shao Y, Luo A, Sun J

Drug design, development and therapy

Apigenin

Arthritis, Sepsis

Anti-Inflammatory Agents, Immunomodulatory, Interleukin-10 upregulation

View abstract

Animal Study

Protective Role of Apigenin-PEGylated Chitosan Nanoparticles Against Pesticide Deltamethrin-Induced Liver Injury via Antioxidant Activation, NF-κB Inhibition, and Bcl-2/Bax/Caspase-3 Signaling Modulation.

Sep 9, 2026 Elmorsy EM, Alshammari AN, Alfawaz MS, Alenezi YM, Abbas MF, El-Raghi AA, Abbas S

Journal of biochemical and molecular toxicology

Apigenin

Chemically-Induced Liver Damage, Pesticide Toxicity

Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor, Anti-Apoptotic, Deltamethrin

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In Vitro Study

Apigenin decreases the pathogenicity of Aeromonas hydrophila infection by inhibiting aerolysin activity and interfering with quorum sensing.

Sep 9, 2026 Li S, Ma X, Zhou S, Ai X, Dong J

Journal of applied microbiology

Apigenin

Aeromonas hydrophila

Anti-Bacterial Agents, Quorum Sensing Inhibition

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Animal Study

Comparative Protective Effects of Melatonin and Apigenin Against Paclitaxel-Induced Testicular Injury in Rats: Oxidative Stress, DNA Damage, Apoptosis, and NF-κB Signaling.

Sep 9, 2026 Saydam F, Altuntoprak M, Bay EB, Mercantepe T, Topcu A, Mataraci Karakas S

Nutrients

Melatonin, Apigenin

Chemotherapy-Induced Toxicity: Paclitaxel, Testicular Injury: Chemical/Metal Induced

Anti-Inflammatory Agents, Antioxidants, Anti-Apoptotic, Chemoprotective Agents

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Animal Study

Passion Fruit Seed Oil as a Natural Tyrosinase Inhibitor: Extraction Optimization, Multi-Mechanism Elucidation, and Efficacy Validation in Zebrafish.

Sep 9, 2026 Li J, Tao Z, Guo Q, Zhang Y, Zhang J, Deng Y, Wu K, Yu H, Chai X, Jiang Y, He D, Liu X, Duan X, Liu J

Foods (Basel, Switzerland)

Passion fruit

Skin Diseases

Tyrosinase Inhibition

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In Vitro Study

Effects of Passiflora edulis Leaf Extract on Lipid Accumulation in HepG2 Cells: In Vitro Evidence and Molecular Docking Analysis Involving PPARα and SREBP-1.

Sep 9, 2026 Aguillón Osma J, León Villarreal JS, Loango Chamorro N

International journal of molecular sciences

Passion Flower

Nonalcoholic fatty liver disease (NAFLD)

Hepatoprotective, Hypolipidemic

View abstract

Animal Study

Protective effects of Passiflora edulis Sims peel fermentation polysaccharide against UVB-induced photodamage via antioxidant and anti-inflammatory activities.

Sep 8, 2026 Fang J, Fang Y, Fu B, Song Z, Zhao J, Sun Q, Li M, Wang C, Wang D

Bioresources and bioprocessing

Passion Flower

Ultraviolet Radiation Induced Damage

Anti-Inflammatory Agents, Antioxidants, Matrix metalloproteinase-3 (MMP-3) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

View abstract

Human Study

Tai Chi exercise improves sleep quality in older adults with mild insomnia by enhancing slow-wave activity during deep sleep: a 12-week randomized controlled trial.

Sep 8, 2026 Lyu M, Cheng J, Li J

Frontiers in physiology

Insomnia

Tai Chi

View abstract

Human Study

Tai Chi Intervention Improves Hypertension by Reshaping the Neuro-Endocrine-Immune Network via the Acetylcholine-Cortisol-TNF-α Pathway.

Sep 8, 2026 Fang H, Li C, Zhou Q, Cui M, Li L, Lyu S, Zhang J

Scandinavian journal of medicine & science in sports

Hypertension

Antihypertensive Agents, Tai Chi

View abstract

Animal Study

Effects of Tai Chi Cloud Hands on balance and resting-state functional connectivity after stroke: an fNIRS study.

Sep 8, 2026 Li J, Dong Z, Fan M, Wang X, Bi Y, Ma Z, Wang S, Wang J, Gong Z

Frontiers in neurology

Andrographolide

Osteoporosis

Antioxidants, Anti-Apoptotic, Osteoprotective

View abstract

Animal Study

Andrographolide ameliorates vascular injury in hypertension by suppressing EndMT via Sp1-Notch1 signaling.

Sep 7, 2026 Tu Q, Li W, Qiu Y, Qiu Y, Liu Z, Zhang M, Liu Z, Xia W, Zhang B, Cao Z, Tao J

Phytomedicine : international journal of phytotherapy and phytopharmacology

Andrographolide

Hypertension

Vasoprotective

View abstract

Human Study

Vitamin D Deficiency Is Associated with Increased Depression Risk in Obese Asthma.

Sep 7, 2026 Liu M, Xiao J, Su J, Ou C, Lin Z, Liu J, Zhou M, Wu A, Liu H, Zhang Q, Zhang X

The journal of allergy and clinical immunology. In practice

Vitamin D

Asthma, Vitamin D Deficiency, Obesity, Depression

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Animal Study

The inhibition of deep peritoneal endometriosis by Andrographolide through macrophage M1 activity in an endometriosis mice model.

Sep 7, 2026 Susianto IA, Susilaningsih N, Hidayat ST, Hardian, Tjandrawinata RR, Rachmawati B

Veterinarni medicina

Andrographolide

Endometriosis

Anti-Inflammatory Agents, Immunomodulatory

View abstract

Animal Study

Andrographolide Attenuates Sepsis-Induced Acute Lung Injury via Peroxisome Proliferator-Activated Receptor Gamma in a Murine Cecal Ligation and Puncture Model.

Sep 7, 2026 Thimmana LV, Kalla HP, Ruhinaz KK, Byalla G, Panati K, Narala VR

Endocrine, metabolic & immune disorders drug targets

Andrographolide

Sepsis, Lung Damage

Antioxidants, Superoxide Dismutase Up-regulation, Catalase Up-Regulation

View abstract

In Vitro Study

Multi-target anti-hangover mechanisms of andrographolide and its analogs: a hypothesis-generating in silico, in vitro feasibility study.

Sep 7, 2026 Jadhav Y, Mukadam S, Bhingoli O, Unavane S, Kamble S, Naidu P, Girme A, Mali A, Shinde V

In silico pharmacology

Andrographolide

Hangover

View abstract

Animal Study

Andrographolide mitigates paraquat-induced pulmonary injury via PI3K/Akt/PPARγ pathway-mediated regulation of EMT and oxidative stress.

Sep 6, 2026 Zhang D, Zhao S, Xiao J, Cai Q, Zhao B

Pakistan journal of pharmaceutical sciences

Andrographolide

Pesticide Toxicity, Lung Damage

Antioxidants, Superoxide Dismutase Up-regulation, Catalase Up-Regulation, Paraquat

View abstract

Animal Study

Evaluation of autologous fecal microbiota transplantation for restoring equine gut microbiota after antibiotic-induced dysbiosis.

Sep 6, 2026 Kinoshita Y, Sato W, Ueno T

Journal of equine veterinary science

Dysbiosis, Antibiotic Toxicity

Gastrointestinal Agents, Microbiota Transfer Therapy

View abstract

Animal Study

Synergistic effects of fecal microbiota transplantation and andrographolide on gut microbiota modulation in dextran sulfate sodium-induced colitis in mice.

Sep 6, 2026 Luo X, Feng J, Sun Y, Tan Z, Wang L, Bao Y, Lu J, He J, Lu B

Frontiers in microbiology

Andrographolide

Colitis

Anti-Inflammatory Agents, Gastrointestinal Agents, NF-kappaB Inhibitor, Microbiota Transfer Therapy

View abstract

Animal Study

Andrographolide Alleviates Liver Damage Caused by Salmonella in Mice by Inhibiting the PANoptosis Pathway.

Sep 6, 2026 Li Q, Hou L, Su L, Wang X, Zhu Y, Fang B

Microorganisms

Andrographolide

Salmonella Infections, Liver Damage

Anti-Bacterial Agents, Hepatoprotective

View abstract

In Vitro Study

Synergistic anti-tumor activity of andrographolide and gemcitabine in intrahepatic cholangiocarcinoma through inhibition of RRM2 and the JAK/STAT3 pathway.

Sep 6, 2026 Song Q, Yu C, Sun F, Wang W, Wen Z, Chen R, Wang Y, Wang H, Wang Z, Li B, Yang L

Cancer chemotherapy and pharmacology

Andrographolide

Cholangiocarcinoma

Apoptotic, Antiproliferative, Chemosensitizer, Cell cycle arrest

View abstract

Research Abstracts Database

Browse All Abstracts

Oleuropein-based olive leaf extract enhances muscle mitochondrial bioenergetics response to moderate - but not maximal - intensity exercise in humans.

Adjuvant treatment with an oleuropein-enriched olive leaf extract improves periodontal outcomes in older adults with periodontitis: Metabolomic insights from a randomized controlled trial.

Health status, risk factors and effects of olive leaf extract infusion (Olea europaea L.) on blood pressure in a hypertensive population.

Hepatoprotective effect of Olea europaea L. leaf against oxidative stress in hepatocytes and zebrafish embryos.

Apigenin Upregulates Regulatory B Cells, Suppresses Class Switch Recombination, and Restores Immune Homeostasis to Treat Autoimmune Arthritis and Sepsis.

Protective Role of Apigenin-PEGylated Chitosan Nanoparticles Against Pesticide Deltamethrin-Induced Liver Injury via Antioxidant Activation, NF-κB Inhibition, and Bcl-2/Bax/Caspase-3 Signaling Modulation.

Apigenin decreases the pathogenicity of Aeromonas hydrophila infection by inhibiting aerolysin activity and interfering with quorum sensing.

Comparative Protective Effects of Melatonin and Apigenin Against Paclitaxel-Induced Testicular Injury in Rats: Oxidative Stress, DNA Damage, Apoptosis, and NF-κB Signaling.

Passion Fruit Seed Oil as a Natural Tyrosinase Inhibitor: Extraction Optimization, Multi-Mechanism Elucidation, and Efficacy Validation in Zebrafish.

Effects of Passiflora edulis Leaf Extract on Lipid Accumulation in HepG2 Cells: In Vitro Evidence and Molecular Docking Analysis Involving PPARα and SREBP-1.

Protective effects of Passiflora edulis Sims peel fermentation polysaccharide against UVB-induced photodamage via antioxidant and anti-inflammatory activities.

Tai Chi exercise improves sleep quality in older adults with mild insomnia by enhancing slow-wave activity during deep sleep: a 12-week randomized controlled trial.

Tai Chi Intervention Improves Hypertension by Reshaping the Neuro-Endocrine-Immune Network via the Acetylcholine-Cortisol-TNF-α Pathway.

Effects of Tai Chi Cloud Hands on balance and resting-state functional connectivity after stroke: an fNIRS study.

Andrographolide ameliorates vascular injury in hypertension by suppressing EndMT via Sp1-Notch1 signaling.

Vitamin D Deficiency Is Associated with Increased Depression Risk in Obese Asthma.

The inhibition of deep peritoneal endometriosis by Andrographolide through macrophage M1 activity in an endometriosis mice model.

Andrographolide Attenuates Sepsis-Induced Acute Lung Injury via Peroxisome Proliferator-Activated Receptor Gamma in a Murine Cecal Ligation and Puncture Model.

Multi-target anti-hangover mechanisms of andrographolide and its analogs: a hypothesis-generating in silico, in vitro feasibility study.

Andrographolide mitigates paraquat-induced pulmonary injury via PI3K/Akt/PPARγ pathway-mediated regulation of EMT and oxidative stress.

Evaluation of autologous fecal microbiota transplantation for restoring equine gut microbiota after antibiotic-induced dysbiosis.

Synergistic effects of fecal microbiota transplantation and andrographolide on gut microbiota modulation in dextran sulfate sodium-induced colitis in mice.

Andrographolide Alleviates Liver Damage Caused by Salmonella in Mice by Inhibiting the PANoptosis Pathway.

Synergistic anti-tumor activity of andrographolide and gemcitabine in intrahepatic cholangiocarcinoma through inhibition of RRM2 and the JAK/STAT3 pathway.